โก Quick Summary
The Danish Lymphoid Cancer Research (DALY-CARE) data resource has been established to enhance data-driven hematology by providing a comprehensive dataset of over 65,000 patients diagnosed with lymphoid-lineage cancers since 2002. This initiative aims to facilitate the development of machine artificial intelligence (mAI) tools that can improve patient care and clinical decision-making.
๐ Key Details
- ๐ Dataset: 65,774 Danish adults with lymphoid-lineage cancer diagnoses since 2002
- ๐งฉ Data Sources: 10 nationwide registers, electronic health records (EHR), and laboratory data
- โ๏ธ Technology: High-powered cloud-computer for secure research environment
- ๐ Data Volume: 21,750 cytoreductive treatment plans, 21.3M outpatient prescriptions, 12.7M in-hospital administrations
๐ Key Takeaways
- ๐ DALY-CARE provides a large-scale data repository for lymphoid cancer research.
- ๐ก Comprehensive data includes treatments, biochemical analyses, comorbidity codes, and survival data.
- ๐ฉโ๐ฌ mAI can be deployed directly into EHR systems to enhance clinical decision-making.
- ๐ฅ Real-world evidence can be generated to evaluate the efficacy of care.
- ๐ The resource supports epidemiological, molecular, and data-driven research.
- ๐ Near real-time decision-support tools can be developed for clinicians.
- ๐ Streamlining health data infrastructure across cohorts and medical specialties is facilitated.
๐ Background
Lymphoid-lineage cancers (LC) encompass a variety of malignancies that share common epidemiological and clinical characteristics. However, the lack of access to large, shared datasets has historically hindered research in this area. The establishment of the DALY-CARE data resource aims to bridge this gap, providing a robust foundation for developing innovative solutions in hematology through data-driven approaches.
๐๏ธ Study
The DALY-CARE initiative involved the collection of electronic health data from all Danish adults diagnosed with lymphoid-lineage cancers since 2002. By integrating data from multiple sources, including nationwide registers and electronic health records, researchers created a comprehensive and secure data repository. This resource is designed to support a wide range of research activities, from epidemiological studies to the development of machine learning algorithms.
๐ Results
The DALY-CARE data resource includes an extensive array of data points, such as 21.3 million outpatient prescriptions, 12.7 million in-hospital administrations, and 77.3 million biochemical analyses. This wealth of information enables researchers to conduct in-depth studies on treatment efficacy, patient outcomes, and the overall healthcare landscape for patients with lymphoid cancers.
๐ Impact and Implications
The establishment of the DALY-CARE data resource represents a significant advancement in the field of hematology. By enabling the development of real-time decision-support tools and facilitating the extrapolation of clinical trial results to everyday practice, this initiative has the potential to greatly enhance patient care. Furthermore, it promotes collaboration across medical specialties, ultimately leading to improved health outcomes for patients with lymphoid-lineage cancers.
๐ฎ Conclusion
The DALY-CARE data resource is a groundbreaking initiative that paves the way for data-driven advancements in hematology. By harnessing the power of comprehensive datasets and machine learning, healthcare professionals can make more informed decisions, leading to better patient outcomes. The future of lymphoid cancer research looks promising, and we encourage continued exploration in this vital area of medicine.
๐ฌ Your comments
What are your thoughts on the potential of the DALY-CARE data resource in transforming lymphoid cancer research? We would love to hear your insights! ๐ฌ Leave your comments below or connect with us on social media:
The Danish Lymphoid Cancer Research (DALY-CARE) Data Resource: The Basis for Developing Data-Driven Hematology.
Abstract
BACKGROUND: Lymphoid-lineage cancers (LC; International Classification of Diseases, 10th edition [ICD10] C81.x-C90.x, C91.1-C91.9, C95.1, C95.7, C95.9, D47.2, D47.9B, and E85.8A) share many epidemiological and clinical features, which favor meta-learning when developing medical artificial intelligence (mAI). However, access to large, shared datasets is largely missing and limits mAI research.
AIM: Creating a large-scale data repository for patients with LC to develop data-driven hematology.
METHODS: We gathered electronic health data and created open-source processing pipelines to create a comprehensive data resource for Danish LC Research (DALY-CARE) approved for epidemiological, molecular, and data-driven research.
RESULTS: We included all Danish adults registered with LC diagnoses since 2002 (n=65,774) and combined 10 nationwide registers, electronic health records (EHR), and laboratory data on a high-powered cloud-computer to develop a secure research environment. Among other, data include treatments (ie 21,750 cytoreductive treatment plans, 21.3M outpatient prescriptions, and 12.7M in-hospital administrations), biochemical analyses (77.3M), comorbidity (14.8M ICD10 codes), pathology codes (4.5M), treatment procedures (8.3M), surgical procedures (1.0M), radiological examinations (3.3M), vital signs (18.3M values), and survival data. We herein describe the data infrastructure and exemplify how DALY-CARE has been used for molecular studies, real-world evidence to evaluate the efficacy of care, and mAI deployed directly into EHR systems.
CONCLUSION: The DALY-CARE data resource allows for the development of near real-time decision-support tools and extrapolation of clinical trial results to clinical practice, thereby improving care for patients with LC while facilitating streamlining of health data infrastructure across cohorts and medical specialties.
Author: [‘Brieghel C’, ‘Werling M’, ‘Frederiksen CM’, ‘Parviz M’, ‘Lacoppidan T’, ‘Faitova T’, ‘Teglgaard RS’, ‘Vainer N’, ‘da Cunha-Bang C’, ‘Rotbain EC’, ‘Agius R’, ‘Niemann CU’]
Journal: Clin Epidemiol
Citation: Brieghel C, et al. The Danish Lymphoid Cancer Research (DALY-CARE) Data Resource: The Basis for Developing Data-Driven Hematology. The Danish Lymphoid Cancer Research (DALY-CARE) Data Resource: The Basis for Developing Data-Driven Hematology. 2025; 17:131-145. doi: 10.2147/CLEP.S479672