โก Quick Summary
This review article explores the molecular mechanisms underlying atherosclerosis, a leading cause of cardiovascular disease, and highlights recent advancements in therapeutic strategies. It emphasizes the importance of integrating multi-omics data and artificial intelligence to enhance precision medicine in managing this complex condition.
๐ Key Details
- ๐ Focus: Atherosclerosis and its pathogenesis
- ๐งฉ Key mechanisms: Endothelial dysfunction, dyslipidemia, immune-inflammatory activation
- โ๏ธ Emerging therapies: Immunomodulatory vaccines, RNA-based therapeutics, biodegradable stents
- ๐ Innovations: Anti-ferroptotic properties in stents, modernized traditional Chinese medicine
๐ Key Takeaways
- ๐งฌ Atherosclerosis is driven by lipid-induced inflammation and arterial remodeling.
- ๐ก Immune cells undergo metabolic reprogramming that contributes to disease progression.
- ๐ Vascular smooth muscle cells exhibit phenotypic switching, impacting vascular health.
- ๐งช Novel therapies include immunomodulatory vaccines and RNA-based treatments.
- ๐ฑ Traditional Chinese medicine formulations are being modernized to target multiple pathways.
- ๐ Integration of technologies like AI and single-cell analysis is crucial for precision medicine.
- ๐ Future research should focus on individualized risk prediction models.
- ๐ Study published in Frontiers in Immunology, 2025.
๐ Background
Atherosclerosis is a chronic vascular condition that significantly contributes to cardiovascular morbidity and mortality. Understanding its complex pathogenesis, which involves a combination of lipid metabolism, inflammation, and immune responses, is essential for developing effective therapeutic strategies. Recent research has shed light on the intricate interactions between various cellular and molecular components that drive this disease.
๐๏ธ Study
The review systematically summarizes recent advances in atherosclerosis research, focusing on the interplay between endothelial dysfunction, dyslipidemia, and immune-inflammatory activation. It discusses key mechanisms such as the metabolic reprogramming of immune cells and the phenotypic switching of vascular smooth muscle cells, which are critical in the progression of atherosclerosis.
๐ Results
The article highlights several innovative therapeutic approaches beyond traditional lipid-lowering strategies. These include immunomodulatory vaccines, RNA-based therapeutics, and biodegradable stents with anti-ferroptotic properties. The integration of modernized traditional Chinese medicine formulations targeting multiple pathways is also discussed, showcasing a holistic approach to treatment.
๐ Impact and Implications
The findings from this review have significant implications for the future of atherosclerosis management. By bridging the gap between molecular mechanisms and clinical practice through the use of multi-omics data and artificial intelligence, healthcare professionals can develop more effective, individualized treatment plans. This could lead to improved patient outcomes and a reduction in cardiovascular events associated with atherosclerosis.
๐ฎ Conclusion
This review underscores the importance of understanding the molecular underpinnings of atherosclerosis and the potential of innovative therapeutic strategies. The integration of advanced technologies and personalized medicine approaches holds promise for transforming the management of this prevalent condition. Continued research in this area is essential to overcome existing challenges and enhance patient care.
๐ฌ Your comments
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Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine.
Abstract
Atherosclerosis, a chronic vascular disease characterized by lipid-driven inflammation and arterial wall remodeling, remains the leading cause of cardiovascular morbidity and mortality. This review aims to systematically summarize recent advances in our understanding of its multidimensional pathogenesis and the corresponding evolution of therapeutic strategies. We focus on the intricate crosstalk between endothelial dysfunction, dyslipidemia, and immune-inflammatory activation, which collectively drive disease progression. Key mechanisms discussed include metabolic reprogramming of immune cells, phenotypic switching of vascular smooth muscle cells, and novel modes of programmed cell death. Beyond conventional lipid-lowering approaches, we highlight emerging therapeutic avenues such as immunomodulatory vaccines, RNA-based therapeutics, and biodegradable stents with inherent anti-ferroptotic properties. Furthermore, we explore the potential of modernized traditional Chinese medicine formulations that target multiple pathways. Looking forward, we conclude that integrating multi-omics data, single-cell technologies, and artificial intelligence is pivotal for advancing precision medicine. This integration will enable the development of individualized risk prediction models and targeted interventions, ultimately bridging the gap between molecular mechanisms and effective clinical management to overcome current bottlenecks in atherosclerosis prevention and treatment.
Author: [‘Han Y’, ‘Xu H’, ‘Yao X’, ‘Li Z’, ‘Zhu C’, ‘Li X’, ‘Chen B’, ‘Sun H’]
Journal: Front Immunol
Citation: Han Y, et al. Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine. Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine. 2025; 16:1737662. doi: 10.3389/fimmu.2025.1737662