โก Quick Summary
This article explores a new paradigm for precision diagnosis and treatment of colorectal cancer through the integration of artificial intelligence (AI) and multi-agent collaboration. By addressing the challenges posed by the high heterogeneity of colorectal cancer, this approach aims to enhance clinical decision-making and improve patient outcomes.
๐ Key Details
- ๐ Focus: Precision diagnosis and treatment of colorectal cancer
- ๐งฉ Technologies: AI foundation models, multimodal data integration
- โ๏ธ Challenges: Information silos in single-modality AI models
- ๐ Proposed Solution: Multi-agent collaboration system simulating multidisciplinary team consultations
๐ Key Takeaways
- ๐ฌ Colorectal cancer presents significant diagnostic and treatment challenges due to its heterogeneity.
- ๐ค AI technologies have shown promise in processing various data modalities, including imaging, genetics, and pathology.
- ๐ Single-modality models struggle to meet the complex needs of clinical decision-making.
- ๐ Multi-agent collaboration could bridge the gap between different data types and enhance diagnostic accuracy.
- ๐ก Future Directions: Integration of AI into clinical practice for improved precision in colorectal cancer management.
- ๐ Study Reference: Cai D, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2026.

๐ Background
The field of colorectal cancer diagnosis and treatment faces considerable challenges due to the high heterogeneity of the disease. Traditional methods often fall short in providing the precision needed for effective treatment. Recent advancements in artificial intelligence offer a promising avenue to enhance diagnostic accuracy and treatment efficacy, paving the way for a more tailored approach to patient care.
๐๏ธ Study
This article reviews the current status of AI technology in colorectal cancer, focusing on the application of foundation models across various data modalities, including imaging, genetics, and pathology. The authors highlight the limitations of single-modality models and propose a novel multi-agent collaboration system that integrates these modalities to simulate a multidisciplinary team (MDT) consultation model.
๐ Results
The findings indicate that while single-modality AI models have demonstrated significant potential, they are insufficient for addressing the complexities of clinical decision-making in colorectal cancer. The proposed multi-agent collaboration system aims to overcome these limitations by integrating diverse data sources, thereby enhancing the precision of diagnosis and treatment.
๐ Impact and Implications
The implications of this research are profound. By leveraging AI and multi-agent collaboration, healthcare providers can achieve a more comprehensive understanding of colorectal cancer, leading to improved patient outcomes. This innovative approach could revolutionize how we diagnose and treat this challenging disease, ultimately enhancing the quality of care for patients.
๐ฎ Conclusion
This article underscores the transformative potential of AI in the realm of colorectal cancer diagnosis and treatment. By moving towards a multi-agent collaboration model, we can better address the complexities of this heterogeneous disease, paving the way for more precise and effective clinical practices. The future of colorectal cancer management looks promising with these advancements!
๐ฌ Your comments
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[A new paradigm for precision diagnosis and treatment of colorectal cancer in the era of artificial intelligence–From foundation models to multi-agent collaboration].
Abstract
The high heterogeneity of colorectal cancer poses significant challenges to clinical precision diagnosis and treatment. In recent years, artificial intelligence (AI) technology, represented by foundation models, has achieved breakthrough progress, offering a new opportunity to address this challenge. AI models based on a single data modality have demonstrated significant application potential in processing data such as imaging, genetics, and pathology; however, their independent analysis mode struggles to meet the needs of complex clinical decision-making. Based on a review of the current application status of AI technology in the field of colorectal cancer diagnosis and treatment, this article focuses on discussing the latest advances in research on single-modality foundation models, including those for imaging, genetics, pathology, and clinical text. It also conducts an in-depth analysis of the “information silos” bottleneck they face. Meanwhile, the article proposes the construction of a “multi-agent collaboration” system that integrates multimodal data and simulates the multidisciplinary team (MDT) consultation model, which is one of the future development directions for achieving precision diagnosis and treatment of colorectal cancer. Focusing on this new paradigm, we combine the preliminary explorations of our team in this field and look forward to its application potential in future clinical practice.
Author: [‘Cai D’, ‘Gao F’, ‘Wu XJ’]
Journal: Zhonghua Wei Chang Wai Ke Za Zhi
Citation: Cai D, et al. [A new paradigm for precision diagnosis and treatment of colorectal cancer in the era of artificial intelligence–From foundation models to multi-agent collaboration]. [A new paradigm for precision diagnosis and treatment of colorectal cancer in the era of artificial intelligence–From foundation models to multi-agent collaboration]. 2026; 29:58-62. doi: 10.3760/cma.j.cn441530-20251009-00371