โก Quick Summary
Recent research reveals that Ginkgetin, an active component of Ginkgo biloba extract, effectively alleviates inflammation and cellular senescence by targeting the cGAS-STING pathway. This study provides a deeper understanding of the molecular mechanisms behind the anti-aging effects of Ginkgetin, paving the way for potential therapeutic applications.
๐ Key Details
- ๐ฑ Extract Studied: Ginkgo biloba
- ๐ฌ Active Component: Ginkgetin
- ๐งฌ Target Pathway: cGAS-STING
- ๐ญ Model Used: Aging mice and Trex1-/- mice
- ๐ Methodology: Graph convolutional network-based drug “on-target” pathway prediction
๐ Key Takeaways
- ๐ Ginkgetin shows promise in combating aging-related disorders.
- ๐งช The study utilized advanced AI algorithms for pathway prediction.
- ๐ Ginkgetin directly binds to the STING protein, inhibiting its activation.
- ๐งฌ In vivo data demonstrated reduced systemic inflammation in aging models.
- ๐ STING is identified as a critical target for Ginkgetin’s effects.
- ๐ The findings provide a theoretical basis for Ginkgo biloba’s therapeutic use.
- ๐ก This research highlights the intersection of AI and pharmacology.
๐ Background
Aging is often accompanied by a range of disorders characterized by chronic inflammation and cellular senescence. Traditional approaches to managing these conditions have limitations, prompting researchers to explore natural compounds with potential therapeutic benefits. Ginkgo biloba, a well-known herbal remedy, has been suggested to possess anti-aging properties, but the specific mechanisms and active components responsible for these effects have remained largely elusive.
๐๏ธ Study
The study aimed to elucidate the role of Ginkgetin, an active ingredient in Ginkgo biloba extract, in alleviating inflammation and senescence. Researchers employed a graph convolutional network-based drug “on-target” pathway prediction algorithm to identify potential molecular targets. The findings indicated that Ginkgetin interacts with the STING protein, a key player in the immune response and inflammation.
๐ Results
The results confirmed that Ginkgetin effectively binds to the carboxy-terminal domain of the STING protein, inhibiting its activation and subsequent signaling pathways. In vivo pharmacodynamic studies demonstrated that Ginkgetin significantly reduced systemic inflammation in Trex1-/- mice and inhibited the aberrant activation of STING signaling in aging mouse models. These findings underscore the potential of Ginkgetin as a therapeutic agent against aging-related inflammation.
๐ Impact and Implications
The implications of this study are profound, as it not only identifies a specific component of Ginkgo biloba with anti-aging properties but also elucidates its molecular mechanism of action. By targeting the STING pathway, Ginkgetin may offer a novel approach to managing inflammation and senescence associated with aging. This research opens avenues for further exploration of natural compounds in the development of therapies for age-related disorders, potentially improving the quality of life for aging populations.
๐ฎ Conclusion
This study highlights the significant potential of Ginkgetin in alleviating inflammation and cellular senescence through its action on the STING pathway. By integrating artificial intelligence with pharmacological research, we gain valuable insights into the therapeutic applications of natural compounds like Ginkgo biloba. Continued research in this area could lead to innovative treatments for aging-related conditions, fostering a healthier aging process.
๐ฌ Your comments
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING.
Abstract
Ginkgo biloba extract is reported to have therapeutic effects on aging-related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient of Ginkgo biloba extract, can alleviate cellular senescence and improve pathologies in multiple tissues of aging mice. To reveal the molecular mechanism of Ginkgetin’s anti-aging effect, a graph convolutional network-based drug “on-target” pathway prediction algorithm for prediction is employed. The results indicate that the cGAS-STING pathway may be a potential target for Ginkgetin. Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy-terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. Furthermore, in vivo pharmacodynamic data showed that Ginkgetin effectively alleviates systemic inflammation in Trex1-/- mice and inhibits the abnormally activated STING signaling in aging mouse model. In summary, this study, utilizing an artificial intelligence algorithm combined with pharmacological methods, confirms STING serves as a critical target for Ginkgetin in alleviating inflammation and senescence. Importantly, this study elucidates the specific component and molecular mechanism underlying the anti-aging effect of Ginkgo biloba extract, providing a robust theoretical basis for its therapeutic use.
Author: [‘Liu Y’, ‘Ye J’, ‘Fan Z’, ‘Wu X’, ‘Zhang Y’, ‘Yang R’, ‘Jiang B’, ‘Wang Y’, ‘Wu M’, ‘Zhou J’, ‘Meng J’, ‘Ge Z’, ‘Zhou G’, ‘Zhu Y’, ‘Xiao Y’, ‘Zheng M’, ‘Zhang S’]
Journal: Adv Sci (Weinh)
Citation: Liu Y, et al. Ginkgetin Alleviates Inflammation and Senescence by Targeting STING. Ginkgetin Alleviates Inflammation and Senescence by Targeting STING. 2024; (unknown volume):e2407222. doi: 10.1002/advs.202407222